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Drug acting on neuromuscular junction Cheat Sheet by

drug acting on neuromuscular junction

Classi­fic­ation Neurom­uscular blocking agent

Pre-ju­nct­ional blocker
Post-j­unc­tional blocker (Non-d­epo­lar­izing
Post-j­unc­tional blocker (Depol­arizing
Antich­oli­nes­terase (Anti-­ACHase) inhibitor
MOA:
1) Prevent Ach release
2) Inhibit Ach synthesis
MOA:
1) Non-de­pol­ari­zing: compete with Ach, inhibit nicotinic Rc
MOA:
Act like Ach, bind to nicotinic Rc
MOA:
Inhibit Anti-A­CHase breaking down Ach
Example:
Butolinum toxin
Aminog­lyc­oside
Example:
d-tubocurarine
Example:
Suxamethonium
Example:
Neostigmine
Edroponium
 
↓ muscle contra­ction
Phase 1: slight muscle contrx
Phase 2: desens­ati­zation, complete paralysis
↑ muscle contra­ction
 

Post-j­unc­tional blocker

NOTE:
- DeP: AntiAchase worsen effect
- NonDeP: AntiAchase reverse effect

List of drug

 

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